Extract High-Quality HMW DNA with Nanobind

When it comes to long-read sequencing, high-molecular-weight (HMW) DNA extraction is a critical first step. Poor quality or fragmented DNA can compromise data accuracy, yield, and throughput. That’s why researchers around the world trust PacBio’s Nanobind kits – a next-generation solution for extracting ultra-pure, ultra-long DNA from a wide variety of sample types.

PacBio’s Nanobind technology features a novel magnetic disk with a micro- and nanostructured silica surface. This unique design enables the gentle capture and release of DNA molecules without shearing, preserving fragment lengths of 50 kb to over 300 kb — ideal for HiFi sequencing.

Unlike traditional spin-column methods that can damage DNA, Nanobind allows you to extract DNA with unmatched integrity and purity, ready for PacBio’s long-read workflows.

✅ Ultra-Pure, Long DNA

Nanobind delivers HMW DNA that meets the stringent quality requirements of PacBio HiFi sequencing, enabling better genome assemblies, structural variant detection, and epigenetic analysis.

✅ Broad Sample Compatibility

Whether you’re working with human tissue, plant nuclei, blood, cultured cells, bacteria, or insects, Nanobind kits are designed to handle it all. Options include:

• Nanobind PanDNA Kit (manual)
• Nanobind CBB Big DNA Kit
• Nanobind Tissue Big DNA Kit
• Nanobind Plant Nuclei Big DNA Kit

✅ Automation-Friendly for High Throughput

For labs processing large numbers of samples, Nanobind HT kits are compatible with automation platforms like Hamilton NIMBUS Presto and Thermo Fisher KingFisher. This enables the processing of up to 96 samples in approximately 2.5 hours, reducing labour time and increasing efficiency.

✅ Simple and Scalable Workflow

The protocol follows a straightforward lyse–bind–wash–elute process. With minimal hands-on time, you can reliably extract DNA across projects of any scale.

The PacBio HiFi sequencing platform delivers industry-leading read accuracy and length – but only if it starts with high-quality DNA. Nanobind ensures:

• High yield and purity for confident long-read analysis
• Consistent performance across sample types and conditions
• Optimised workflows for low- and high-throughput labs

Researchers aiming to generate accurate de novo assemblies, uncover structural variants, or explore methylation patterns can depend on Nanobind to deliver the DNA quality required.

Nanobind kits are ideal for a wide range of research applications, including:

• Whole genome sequencing (WGS)
• Structural variant discovery
• Microbiome and metagenomics
• Agricultural genomics
• Rare disease research
• Complex plant and animal genomes