Codex DNA

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BioXp™ 3250 system

The BioXp™ 3250 system provides hands-free, end-to-end automation of DNA assembly, cloning, amplification, and mRNA synthesis in a single overnight run

The award-winning  BioXp™ 3250 system accelerates the design-build-test phases of the product development cycle by enabling automated, rapid, high-throughput synthesis of genes, clones, variant libraries and mRNA. The BioXp™ system is designed to improve productivity, reduce turnaround time, increase throughput and scale, enhance quality, and enable complete workflow control for both synthetic DNA and mRNA formats.

  • Eliminates critical bottlenecks + accelerates workflows from weeks and months to days and hours
  • First + only push-button system for on-demand biologics printing (DNA, RNA, proteins)
  • Unprecedented quality + performance category winner in speed, fidelity, complexity (AI), build size, and scale
  • 20–50x productivity increase during design, build phases, resulting in accelerated product development cycles
  • Potential to enable global distributed manufacturing for mRNA therapeutics, vaccines, and biologics

Workflows

mRNA-based Therapeutics
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An mRNA-based approach to
therapeutics has recently
emerged as an alternative
to monoclonal antibody-based drugs
Genome Editing

High-throughput design for CRISPR experiments
Genome Synthesis

Engineer large, complex, fully-synthetic genomes
     
Metabolic engineering
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Reconstruct and optimise biosynthetic pathways with speed and accuracy
Antibody Drug Discovery
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Advance discovery by accelerating screening and optimisation
Immune Monitoring
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Rapid screening for safe, responsive immunotherapy treatment
     
Synthetic mRNA
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Accelerating discovery by automating mRNA synthesis
Vaccine Development & Discovery
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Accelerate development and improve efficiency
Precision Medicine
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Increase throughput. Eliminate contaminants and immunogenicity.

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Products

mRNA synthesis - Automate and accelerate DNA sequence to mRNA

BioXp™ small-scale mRNA synthesis kit 
Contains all the Gibson Assembly® reagents necessary to synthesize up to ten micrograms of biologically active synthetic mRNA using de novo synthesized, error-corrected gene fragments (mRNA template) of up to 1.8 kb in length. 
Through the power of the BioXp™ system and application-specific BioXp™ kits, Codex DNA enables push-button, walk-away, end-to-end automation of important synthetic biology workflows.

Product Specifications:

  • Size:  0.3–1.8 kb
  • Yield (length- and sequence-dependent): 1–10 µg
  • Features:  5' ARCA cap; poly(A) tail (median: 150 As)
  • Throughput:  8 or 16 samples per run
  • Classification:  RUO reagents

 

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Gene Synthesi s - Any size. On demand. In your lab. 

BioXp™ gene synthesis kit
BioXp™ gene synthesis kits contain all of the Gibson Assembly® reagents necessary to make error-corrected, de novo synthetic gene fragments of up to 1.8 kb in length. 
Through the power of the BioXp™ system and application-specific BioXp™ kits, Codex DNA enables push-button, walk-away, end-to-end automation of important synthetic biology workflows.

Product specifications:

  • Size: 0.3–1.8 kb
  • Vector options: Codex DNA vector or your own
  • Price: Starting at 8¢ per bp
  • Minimum order: 1 gene
  • Yield: 100 ng–15 μg
  • System runtime: < 18 hours
  • Total turnaround time: 3–5 days from order to cloned genes

 

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DNA cloning - Build complex DNA constructs overnight, on your benchtop

BioXp™ DNA cloning kits
BioXp™ DNA cloning kits contains all of the Gibson Assembly® reagents necessary to make error-corrected, de novo synthetic genes of up to 7 kb in length. These can use either the standard made-to-stock vectors or your specific custom vector. 
Through the power of the BioXp™ system and application-specific BioXp™ kits, Codex DNA enables push-button, walk-away, end-to-end automation of important synthetic biology workflows.

Product specifications

  • Size: 300 to 7,000 base pairs
  • Yield: 200 ng to 10 μg
  • System runtime: 6 to 21 hours; variable, based on application
  • Total turnaround time: 3 to 5 days from order to cloned genes

For laboratory scientists performing high-throughput applications that require a rapid turnaround time of error-free clones, the BioXp™ system is the ideal platform for rapidly building high-fidelity constructs. The BioXp™ workflow enables scientists to generate guaranteed error-free clones in under one week, resulting in greater productivity.

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DNA Amplification - Build and amplify complex DNA constructs quickly

BioXp™ RapidAMP™ cell-free DNA amplification kit

BioXp™ RapidAMP™ cell-free DNA amplification kits contain all of the Gibson Assembly® reagents necessary to amplify error-corrected genes, cloned into either a made-to-stock or customer vector, to make up to ten micrograms of DNA.
Through the power of the BioXp™ system and application-specific BioXp™ kits, Codex DNA enables push-button, walk-away, end-to-end automation of important synthetic biology workflows.

Cloning without E. coli — get to your results faster. Get to your results faster and in fewer steps with Gibson Assembly® RapidAMP™ isothermal amplification. Assemble and amplify transfection-ready DNA in a simple two-day workflow. Achieve over 10 µg of high-quality, high-fidelity DNA with RapidAMP™ technology, and skip the tedious tasks associated with transformation, cell culture, and E. coli harvest.

Product Specifications:

  • Max # of fragments assembled:  4
  • Cloning efficiency:  95% full-length clones
  • Insert size range:  300–1,800 bp
  • Total construct size range:  10,000 bp
  • Reaction time:  80 minutes + 4 hours

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Build DNA variant libraries - Synthetic DNA, simplified

BioXp™ libraries kits are available with varied single contiguous amino acid sites, including site-saturation such as NNN, NNK, or any other IUPAC nucleotide code, varied single contiguous alanine sites, or varied, multiple non-contiguous amino acids sites using degenerate bases to optimize protein binding and function. Through the power of the BioXp™ system and application-specific BioXp™ kits, Codex DNA enables push-button, walk-away, end-to-end automation of important synthetic biology workflows.

Scanning libraries

BioXp™ site saturation scanning libraries kits and BioXp™ alanine scanning libraries kits provide a wide variety of scanning libraries with varied single, contiguous amino acid sites, including site-saturation (NNN, NNK) and alanine scanning libraries. Design and build your own custom libraries or let our expert team guide you.

Product Specifications:

  • Product format:  Linear double-stranded DNA
  • Output:  96-well plate; 32 variants per plate; 1 position per well
  • Yield:  200 ng–1 µg per position (length-dependent)
  • Minimum order:  32 variants
  • System runtime:  from 6-7 hours
  • Total turnaround time:  3-5 days from order to built libraries

 

Combinatorial libraries

BioXp™ combinatorial libraries kits provide a wide variety of combinatorial libraries with varied, multiple non-contiguous amino acids sites using degenerate bases to optimize protein binding and function. Design and build your own custom libraries or let our expert team guide you.

Product Specifications:

  • Product format:  Linear double-stranded DNA
  • Output:  96-well plate; 32 variants per plate; 1 library per well
  • Yield:  200 ng–1 μg per position (length-dependent)
  • System runtime:  6–7 hours
  • Total turnaround time:  3–5 days from order to built libraries

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