Kits & Accessories

Product list

Kits

Accessories


 

Kits

LUNARIS™ Kits include all components necessary to perform the assay and readout on the LUNARIS™ Reader: LUNARIS™ BioChips, diluents, buffers, reagents, standards, LUNARIS™ Decoding File, LUNARIS™ Analysis Suite, and instructions for use.

 

Immuno-Oncology

2019-07-31_8-32-08.jpgCytokine profiles offer a telltale snapshot of immune function that can inform treatment decisions in next-generation cancer therapies. Progress in stem cell therapy can be monitored, adding valuable information for decisions about next treatment steps. Sensitive detection of cytokines can reveal susceptibility of cancer tumors to immune-based strategies like adoptive T cell-mediated immunotherapy, or to antibody-based cancer drugs.

Ayoxxa's immuno-oncology cluster of LUNARIS™ Kits enables sensitive detection of multiple relevant cytokines in a single, small, minimally invasive biofluid sample

LUNARIS™ Human 11-Plex Cytokine Kit

Sensitive quantification of key inflammatory biomarkers involved in regulating differentiation and effector functions of Th1 and Th2 cells, including eight interleukins, granulocyte macrophage colony stimulating factor (GM-CSF), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α).

LUNARIS™ Human 6-Plex T Cell Characterization Kit

Quantify six soluble effector molecules secreted by T cells that serve as biomarkers of specific population subsets. Resulting profiles discriminate Th1, Th2, Th17, Treg, and cytotoxic T cells based on the detection of IFN-γ, IL-4, IL-17A, TGF-β1, and Granzyme B, respectively. IL-2 is concurrently measured to assess T cell proliferation.

LUNARIS™ Human 5-Plex Cytokine Kit

Validated with clinically relevant samples, the LUNARIS™ Human 5-Plex Cytokine Kit quantifies five inflammatory cytokines at single-digit pg levels and over a dynamic range spanning 3–4 orders of magnitude.

LUNARIS™ Human 4-Plex Cytokine Kit

A focused panel that enables sensitive quantification of inflammatory biomarkers involved in regulating the differentiation and effector functions of Th1 cells, including interleukins IL-2, IL-12p70, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α).

LUNARIS™ Human 3-Plex Cytokine A Kit

Gain insights into mechanisms of acute-phase responses to inflammation with this targeted panel that sensitively quantifies biomarkers IL-1β, IL-6, and tumor necrosis factor-α (TNF-α).

LUNARIS™ Human 3-Plex Cytokine Kit

A focused panel that enables sensitive quantification of inflammatory biomarkers involved in regulating the differentiation and effector functions of Th2 cells, including interleukins IL-4, IL -5, and IL-10.

LUNARIS™ Mouse 6-Plex T Cell Characterization Kit

A panel to detect 6 soluble effector molecules secreted by distinct murine T cell populations. Measure IFN-γ, IL-4, IL-17A, TGF- β1, and Granzyme B to identify Th1, Th2, Th17, Treg, and cytotoxic T cells. IL-2 is included in the panel to assess T cell proliferation.


 

Inflammation/Cytokines

2019-07-31_8-31-25.jpgUnderstanding mechanisms and effects of inflammation can inform a range of medical questions in allergy management, autoimmunity, intra- and extracellular pathology, cell-mediated and humoral immune responses.

Ayoxxa's inflammation cluster of LUNARIS™ Kits targets meaningful selections of secreted and soluble cytokines implicated in T cell differentiation and effector functions. Unlike other comparable cytokine quantification methods, the kits allow measuring protein concentrations from single-digit pg/mL levels to 3–4 log scales higher in low-volume clinical samples.

LUNARIS™ Human 12-Plex Th17 Kit

A panel of 12 biomarkers involved in regulating the differentiation and effector functions of human Th17 cells. Measurement of active transforming growth factor β1 (TGF-β1) plus interleukins IL-6 and IL-23, is complemented with sensitive quantification of IL-1β, IL-4, IL-17A, IL-17E. IL-17F, IL-21, CCL20, and interferon-γ (IFN-γ).

LUNARIS™ Human 11-Plex Cytokine Kit

Sensitive quantification of key inflammatory biomarkers involved in regulating differentiation and effector functions of Th1 and Th2 cells, including eight interleukins, granulocyte macrophage colony stimulating factor (GM-CSF), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α).

LUNARIS™ Human 11-Plex Chemokine Kit

A sensitive quantification of 11 human chemokines involved in cell trafficking and effector functions of lymphocytes, granulocytes, and mononuclear cells. The profiled analytes include chemokines from the CC subfamily (CCL2, CCL3, CCL4, CCL5, CCL11, CCL19, and CCL20) as well as the CXC subfamily (CXCL1, CXCL8 (IL-8), CXCL10, and CXCL12).

LUNARIS™ Human 6-Plex T Cell Characterization Kit

Quantify six soluble effector molecules secreted by T cells that serve as biomarkers of specific population subsets. Resulting profiles discriminate Th1, Th2, Th17, Treg, and cytotoxic T cells based on the detection of IFN-γ, IL-4, IL-17A, TGF-β1, and Granzyme B, respectively. IL-2 is concurrently measured to assess T cell proliferation.

LUNARIS™ Human 6-Plex Th17 Kit

A panel of six interleukins involved in regulating the differentiation and effector functions of human Th17 cells. Measurement of IL-1β, IL-6, IL-21, and IL-23 is complemented with sensitive quantification of biomarkers IL-17A and IL-17F.

LUNARIS™ Human 5-Plex Cytokine Kit

Validated with clinically relevant samples, the LUNARIS™ Human 5-Plex Cytokine Kit quantifies five inflammatory cytokines at single-digit pg levels and over a dynamic range spanning 3–4 orders of magnitude.

LUNARIS™ Human 4-Plex Cytokine Kit

A focused panel that enables sensitive quantification of inflammatory biomarkers involved in regulating the differentiation and effector functions of Th1 cells, including interleukins IL-2, IL-12p70, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α).

LUNARIS™ Human 3-Plex Cytokine A Kit

Gain insights into mechanisms of acute-phase responses to inflammation with this targeted panel that sensitively quantifies biomarkers IL-1β, IL-6, and tumor necrosis factor-α (TNF-α).

LUNARIS™ Human 3-Plex Cytokine B Kit

Gain insights into T follicular helper (Tfh) cell function by quantifying human inflammatory cytokines IL-6, IL-10 and IL-21, which are involved in regulating their differentiation and effector functions.

LUNARIS™ Human 3-Plex Cytokine Kit

A focused panel that enables sensitive quantification of inflammatory biomarkers involved in regulating the differentiation and effector functions of Th2 cells, including interleukins IL-4, IL -5, and IL-10.

LUNARIS™ Mouse 12-Plex Th17 Kit

The 12 biomarkers of this panel are involved in regulating the differentiation and effector functions of murine Th17 cells and have human analogs, making this kit a powerful tool for connecting insights from cell and animal models to human biology. Measurement of active transforming growth factor β1 (TGF-β1) plus interleukins IL-6 and IL-23, is complemented with sensitive quantification of IL-1β, IL-4, IL-17A, IL-17E, IL-17F, IL-21, CCL20, and interferon-γ (IFN-γ).

NEW: LUNARIS™ Mouse 12-Plex Chemokine Kit

Quantify 12 murine chemokines involved in cell trafficking and effector functions of lymphocytes, granulocytes and mononuclear cells. The profiled analytes include chemokines of the CC subfamily (CCL2, CCL3, CCL4, CCL5, CCL11, CCL19, CCL20, and CCL22), as well as the CXC subfamily (CXCL1, CXCL10, CXCL12). The panel covers also CX3CL1 (Fractalkine).

LUNARIS™ Mouse 6-Plex T Cell Characterization Kit

A panel to detect 6 soluble effector molecules secreted by distinct murine T cell populations. Measure IFN-γ, IL-4, IL-17A, TGF- β1, and Granzyme B to identify Th1, Th2, Th17, Treg, and cytotoxic T cells. IL-2 is included in the panel to assess T cell proliferation.

LUNARIS™ Mouse 6-Plex Th17 Kit

A focused panel of 6 interleukins involved in regulating the differentiation and effector functions of murine Th17 cells. Measurement of IL-1β, IL-6, IL-21, and IL-23 is complemented with sensitive quantification of IL-17A and IL-17F.

LUNARIS™ Mouse 3-Plex Cytokine B Kit

Gain insights into murine T follicular helper (Tfh) cell function by quantifying inflammatory interleukins IL-6, IL-10 and IL-21, which are involved in regulating their differentiation and effector functions.


 

Ophthalmology

2019-07-31_8-31-53.jpgResearch over the last few decades has uncovered a growing number of biomarkers of eye diseases and dysfunctions that have proven indispensable as diagnostic and therapeutic indicators.

The ophthalmology cluster of LUNARIS™ Kits constitutes a trailblazing solution for examining cytokines, angiogenesis markers, and chemokines associated with eye pathologies because they enable their detection in rare, low-volume and even viscous ocular samples from human clinical interventions or mouse models.

LUNARIS™ Human 11-Plex Ophthalmology Kit

A panel of mediators in retinal angiogenic diseases and key inflammatory markers relevant to ophthalmic conditions. Quantify three chemokines (CXCL), angiopoietin-2 (Ang-2), monocyte chemoattractant protein-1 (MCP-1/CCL2), C-reactive protein (CRP), platelet-derived growth factor-BB (PDGF-BB), placental growth factor (PlGF), vascular endothelial growth factor-A (VEGF-A), plus interleukins IL-6 and IL-8 in human ocular fluids, plasma, or tears.

LUNARIS™ Mouse 6-Plex Ophthalmology Kit

A carefully selected panel of key mediators in retinal angiogenic diseases. Kit performance is optimized for the quantification of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), CCL2, insulin-like growth factor-1 (IGF-1), platelet-derived growth factor-BB (PDGF-BB), and vascular endothelial growth factor-A (VEGF-A) in murine ocular fluids.


 

Accessories

Depending on the number in use, BioChips from LUNARIS™ Kits are held on a high-precision, reusable LUNARIS™ BaseFrame to ensure correct positioning during readout. Assembled, BioChips and BaseFrame have a standard microtiter plate format. A lid covers and protects the assembly throughout an experiment. Tara BioChips are also available as  counterbalance in centrifugation steps of assay preparation.

These accessories are bundled in a convenient LUNARIS™ Accessory Kit, which needs to be purchased only once to start your multiplexing experiment.

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