Norgen Biotek Blood Storage Tubes Best for Preserving miRNA, Genetic Material, Study Finds

norgen-logo.jpgThe unique cf-DNA/cf-RNA Preservative Tubes from Norgen were found to be the most suitable for liquid biopsy when compared to other leading competitor's blood collection tubes (BCTs). This finding can be viewed in a recent publication in the International Journal of Medical Sciences which highlights the key benefits of Norgen's cf-DNA/cf-RNA Preservation Tubes for the analysis of circulating nucleic acids in liquid biopsies


Scientists at the University Hospital of Heidelberg and the German Cancer Center carried out studies to test the limits of conventional EDTA tubes as well as long-term storage blood collection tubes (BCTs) from four different manufacturers for their potential applications in clinical diagnostics, including Norgen's cf-DNA/cf-RNA Preservative Tubes, Streck's Cell-Free DNA Tubes, Roche Diagnostic's Cell-Free DNA Collection Tube and PreAnalytiX's PAXgene Blood ccfDNA Tubes.

Their findings were recently published in the paper "Evaluation of Storage Tubes for Combined Analysis of Circulating Nucleic Acids in Liquid Biopsies", and the following conclusions were made:

  • Norgen's tube is one of the best at stabilizing cf-miRNAs, and thus the most suitable for clinical use when performing liquid biopsies.
  • In terms of stability of cfDNA, they found that "Norgen outperformed the other manufacturers in the amount of cfDNA isolated".
  • Norgen's tubes do not rely on formaldehyde fixation, which is a harsh treatment, as well as the fact that blood can be stored for up to 30 days before processing.
  • Norgen's tubes are "compatible for the extraction of both cfDNA and cfRNA, whereas the other manufacturers supply separate tubes for RNA analysis, making it more costly not only financially but also in terms of the sample amount available.  Therefore, for combinatorial marker studies, Norgen tubes are desirable".
  • No hemolysis was observed in PAX and Norgen tubes for up to one week, indicating that either of these tubes may be the best choice when analyzing both cf-miRNA and cfDNA stored for up to 1 week.

Check the recent GenomeWeb article here and Contact us today for your Norgen samples and pricing.



Enquiry Form

Required fields are marked with*