The world's largest antibody manufacturer
NanoAb Service
VHH antibody, also known as Camelid single domain antibody (sdAb), is the recombinant variable domain derived from camelid heavy-chain-only antibody. This configuration confers a number of unique properties. The small size and high stability of VHH antibody make it a promising tool for disease diagnosis and treatment. VHH antibody can penetrate tissue more easily and target difficult epitopes hidden in the protein structure. Additionally, VHH antibody expresses well in many host systems, making it cost-effective for large-scale manufacturing.
Abnova offers the NanoAb™ service for the production of target-specific VHH antibodies from the camelid VHH library. Using advanced camelid VHH library screening technology, we screen the library and isolate the VHH clones for your required antigens. Positive clones are sequenced and validated by ELISA. The selected clones will then be introduced into the HEK293 expression vector or E. coli expression vector for transient and scalable VHH antibody production, suitable for many downstream applications.
NanoAb workflow
Specifications
Advantages
- Small Size
- Low Immunogenicity
- Fast Blood Clearance
- Easy Conjugation
- Robustness in Bioengineering
- Superior Stability
- High Affinity and Specificity
- Versatile Production
- Easy Multimerization (Multivalency/Multiparatopicity/Multispecificity)
- Applications Across Fields
VHH Antibody vs. Conventional Mab and Pab
