10x Genomics

On this page:

Chromium Single Cell

Visium Spatial


Top of page

Visium Service Site

Grant Writing Resources

Single cell reference sites

Chromium Single Cell Gene Expression Flex

Single cell technology is now better equipped to help unravel biological complexity. The latest addition to the Chromium platform, Single Cell Gene Expression Flex, brings our most sensitive single cell assay to your bench, with flexible options for everything from pilot experiments to million-cell studies.

This powerful probe-based assay boosts your discovery power, enabling you to:

  • Run assays on your schedule and simplify handling with the ability to store and transport samples without losing data quality
  • Batch and multiplex samples to improve efficiency, minimize handling, and reduce per-sample costs by up to 75%
  • Start from fresh or PFA-fixed samples, or even FFPE tissues from clinical trials or other translational studies

Learn more

Top of page

Single Cell Gene Expression

Profile thousands of genes at the single cell level for unbiased characterization of cell types and cell states

  • Combine gene expression analysis with detection of hundreds of cell surface proteins at high resolution for ultra-high parameter multiomic cytometry
  • Use with Targeted Gene Expression panels to focus on the genes and biomarkers most relevant to your research
  • Simultaneously assess CRISPR perturbation phenotypes and gene expression from the same cell to accelerate your functional genomics studies
  • Leverage dual index libraries for reliable sequencing data quality
  • Combine with 3' CellPlex to multiplex up to 12 samples and recover up to 17,500 singlets* per channel, enabling larger-scale single cell studies
  • Singlets are single cells or nuclei captured after multiplet removal.
  • Level up your insights by combining single cell gene expression data with spatial gene expression

Product Sheet   Learn More

Top of page

Single Cell Immune Profiling

Profile thousands of genes at the single cell level by barcoding mRNA at the 5' end, for unbiased characterisation of cell types and cell states

  • Simultaneously profile immune repertoire (BCR/TCR) and gene expression from the same cell to enable correlation of clonotype with the corresponding cell subtype
  • Obtain paired, full-length receptor sequences from T cells and/or B cells with complete isotype resolution, providing functional data for antibody/TCR discovery
  • Combine gene expression analysis with detection of hundreds of cell surface proteins at high resolution for ultra-high parameter multiomic cytometry
  • Combine with Targeted Gene Expression Panels to focus on the genes that matter most and accelerate your studies into actionable insights
  • Utilise product partners for Feature Barcode technology (oligo-conjugated antibodies, oligo-conjugated MHCs) to easily perform multiomic profiling
  • Leverage dual index libraries for superior sequencing data quality

Product Sheet   Learn more

Top of page

Single Cell Multiome ATAC + Gene Expression

The first commercial single cell multiomics product for simultaneous profiling of gene expression and chromatin landscape at single cell resolution.

Capture multiple measurements simultaneously at the single cell level for deeper characterisation of cell types and states

  • Integrate gene expression with epigenomic landscape through direct measurements from the same cell, eliminating the need for computational inference across datasets
  • Link open chromatin regions and target genes to discover new gene regulatory interactions
  • Obtain multiple measurement types from the same cell to maximize insights from limited samples
  • Take advantage of a simple and robust workflow for straightforward experimental setup
  • Apply easy-to-use data analysis and visualisation software for powerful data interpretation

Product Sheet: Simultaneous profiling of the transcriptome and epigenome from the same cell

Learn more

Top of page

Single Cell ATAC

Chromium Single Cell ATAC v2 is now shipping!

Chromium Single Cell Assay for Transposase Accessible Chromatin (ATAC) is a powerful method to understand gene regulation and characterise cell types and states, all at the single cell level. Building upon v1.1 chemistry, the v2 assay provides increased sensitivity and improved signal-to-noise ratio, enhancing your ability to detect rare peaks.

  • 50% higher sensitivity, depending on sample type
  • Increased usable reads, thereby improving signal-to-noise ratio
  • Deeper characterisation of complex samples, including enhanced ability to detect rare peaks
  • Compatibility with the new Chromium Nuclei Isolation Kit, an easy-to-use kit optimised for 10x Genomics single cell assays, which streamlines sample prep for a wide range of frozen sample types.

Product Sheet: Profiling chromatin accessibility at single cell resolution

Learn more

Top of page

Nuclei Isolation

Prep for success: 

10x Genomics' new Chromium Nuclei Isolation Kit removes the complexities of nuclei isolation with an easy-to-use solution specifically designed for use with 10x Genomics single cell assays for gene expression and chromatin accessibility.

  • Save precious samples and remove the guesswork from nuclei prep with a unified, optimised workflow
  • Easily and efficiently prepare frozen samples with an all-in-one kit for multiple tissue types
  • Streamline your workflow and process up to 8 samples in just 1 hour

What sample types are compatible with the Chromium Nuclei Isolation Kit

Product sheet  Learn more

Top of page

Single Cell CRISPR Screening

10x Genomics 5' CRISPR is now available for order and shipment!

5' CRISPR Product Sheet | CRISPR Infographic | User Guide & Protocols

  • Evaluate entire gene networks, key disease pathways, or specific gene functions with multiomic, single cell profiling of up to thousands of CRISPR-driven gene edits
  • Perform large-scale pathway screens to access more information per target, enabling more confident decision making for drug candidates
  • Validate hits from genome-wide association studies (GWAS) and obtain comprehensive functional information from CRISPR edits to elucidate gene function

What is the difference between the 10x Genomics Single Cell 5' and 3' CRISPR Screening assays, and which should I use?

Our 5' CRISPR screening assay is compatible with most pre-existing Cas9 guide RNA vectors. If you have an existing CRISPR library or are starting a single cell CRISPR screen for the first time, we recommend using our Single Cell 5' v2 assay which is compatible with most guide libraries with little to no optimization required.

Our 3' CRISPR screening assay requires that a specific Capture Sequence be inserted into the vector at the appropriate location for capture of the guide. If you want to compare your single cell CRISPR experiment to data from previous experiments using 3' single cell gene expression with Feature Barcode technology, we recommend continuing to use our Single Cell 3' v3.1 assay to minimize batch effects.

A clear path to gene function with single cell CRISPR screening

Learn more

Top of page

5' Barcode Enabled Antigen Mapping (BEAM)

Comprehensive antigen-specific clonotype discovery in one week

BEAM (Barcode Enabled Antigen Mapping) is a multiplexed antigen screening workflow that empowers rapid discovery of antigen-specific B-cell (BEAM-Ab) and T-cell (BEAM-T) clonotypes. Obtain comprehensive antigen-specific cellular profiles—including full-length paired V(D)J sequences, gene expression, and cell surface proteins at single cell resolution—to identify rare, antigen-reactive T and B cells for accelerating therapeutic discovery.

Learn more


Transform antibody discovery with the fastest hit generation workflow, powered by multiplexed antigen screening against thousands of single B cells.

  • Go from sample to high-quality antibody hits in under a week
  • Screen up to 15 antigens in parallel to generate tens to hundreds of hits per sample
  • Easily identify the ideal antibody candidates for downstream validation


Antigen-specific T cells don't have to be hard to find anymore. Map antigens to T-cell receptors with off-the-shelf ease and unparalleled cellular characterisation.

  • Leverage kitted, custom loadable MHC monomers to prepare peptide-MHC complexes in minutes
  • Design and source peptides from any vendor for maximum flexibility
  • Detect rare and/or therapeutically relevant TCR clonotypes with gene expression at single cell resolution

Top of page

Spatial Gene Expression (Visium)

Visualise gene expression within the tissue context.  Available for FFPE and Fresh Frozen samples.

  • Integrate easily with your current laboratory methods and tools for tissue analysis, letting you start your Spatial Gene Expression experiments immediately
  • Avoid the need for dissociating your samples before conducting gene expression studies to retain spatial context
  • Broaden your reach beyond predefined regions of interest to analyse the entire tissue section at once so you don't miss out on unanticipated results
  • Combine with immunofluorescence staining and imaging to gain multiomic characterisation in the spatial context
  • Combine with Targeted Gene Expression Panels to focus on the genes that matter most and accelerate your studies into actionable insights
  • Experience unparalleled insights—full tissue coverage, high resolution, increased sensitivity, and greater depth

Fresh Frozen - Product Sheet   FFPE - Product Sheet

Learn more

Top of page

Visium Spatial Proteogenomics

  • Combine whole transcriptome spatial analysis with immunofluorescence protein detection in the same tissue section.
  • Gain a deeper, more holistic understanding of tissue organisation with colocalized protein detection and gene expression analysis.

  • Go back in time—Apply new biomarkers to archived FFPE samples and uncover hidden biology from the past
  • Multiomic analysis—Characterise heterogeneity more completely with spatial multomic analysis of protein and mRNA to a single tissue section
  • Powerful discovery—Envision the spatial organization of newly discovered cell types, states, and biomarkers with protein detection and whole transcriptome analysis.

Gain a new perspective on tissue complexity with simultaneous gene and protein spatial profiling

Learn more

Top of page


Whether you're just starting out with single cell, expanding your capabilities, or seeking an automated way to partition individual cells and generate barcoded, sequencing-ready libraries, you're covered. 10x Genomics' proven Next GEM technology provides a trusted path to advance your understanding of cell diversity and function.

Chromium X Series

The most flexible way to single cell.

Expand your single cell capabilities with the most advanced hardware and highest throughput flexibility, enabling multiomic analysis of hundreds to millions of cells.

Learn more

Chromium Controller

Perform multiomic analysis of hundreds to tens of thousands of single cells with this compact system.

Assay compatibility:

  • Single Cell Gene Expression LT
  • Single Cell Gene Expression
  • Single Cell Immune Profiling
  • Single Cell ATAC
  • Single Cell Multiome ATAC + Gene Expression

Learn more

Top of page

Chromium Connect

Combine single cell partitioning, barcoding, and/or library construction with standardised, automated workflows to maximize your productivity.

  • Obtain consistent and reproducible single cell gene expression libraries
  • Automate your single cell library preparation workflow with maximum walk-away convenience
  • Single cell suspensions to final sequencing-ready libraries
  • Parallel processing between 1 to 8 samples per run

Learn more

Top of page

Visium CytAssist 

Seamlessly transition between standard histology workflows and analyte capture onto Visium slides for in-depth expression analysis.

With Visium CytAssist you can:

  • Study FFPE specimens archived in blocks or on slides
  • Expand ongoing studies of fresh frozen samples
  • Preview tissue section integrity, morphology, and staining patterns
  • Use your slides, annotate your images, choose the best sections
  • Select from powerful spatial expression tools for whole transcriptome, targeted, proteomic, or multiomic studies
  • Quickly and easily capture sample analytes for spatial library creation with Visium Spatial Solutions

Workflow: Facilitate transfer of transcriptomic analytes in FFPE samples with Visium CytAssist

Product Sheet   Learn more

Top of page

Xenium In Situ

Build spatial transcriptome maps with Xenium In Situ

The Xenium workflow starts with sectioning tissues onto a microscope slide. The sections are then treated to access the RNA for labeling with circularizable DNA probes. Ligation of the probes then generates a circular DNA probe which is enzymatically amplified and bound with fluorescent oligos, creating bright, easy to image signal that has a high signal-to-noise ratio. The slide is then placed in the Xenium In Situ Analyzer where the sample then undergoes successive rounds of fluorescent probe hybridization, imaging, and removal. An optical signature specific to each gene is generated, enabling identification of the target gene. Finally, a spatial map of the transcripts is built across the entire tissue section.

Product Sheet   Learn more

Top of page

Top of page

Chromium Technology

This proprietary Next GEM technology fuels our Chromium System with an innovative reagent delivery system, set of algorithms and turnkey software analysis tools that enable the discovery of previously inaccessible genetic information at massive rate and scale.

The Next GEM technology is built on a new chip architecture that integrates seamlessly into existing solutions. This technology will enable future solutions and product improvements. The Next GEM technology combines new chips and reagents, and is currently offered for the following solutions:

  • Chromium Single Cell Gene Expression
  • Chromium Single Cell Immune Profiling
  • Chromium Single Cell ATAC

Learn more

Top of page

Visium (Spatial Biology) Technology

Uncover the "where" for every "What".

The relationship between cells and their relative locations within tissue is critical to understanding normal development and disease pathology. Spatial transcriptomics is a groundbreaking molecular profiling method that allows scientists to measure all the gene activity in a tissue sample and map where the activity is occurring. Already this technology is leading to new discoveries that are proving instrumental in helping scientists gain a better understanding of biological processes and disease.

Available for:

  • FFPE samples
  • Fresh Frozen samples

Learn more

Top of page

Enquiry Form

Required fields are marked with*